RNA Details
Disease Name
myocardial infarction
Tissue
heart
RNA Symbol
mir-27a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
bioinformatic analyses;luciferase assays
Target
GFPT2
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Promoting roles of KLF5 in myocardial infarction in mice involving microRNA-27a suppression and the following GFPT2/TGF-beta/Smad2/3 axis activation
Year
2021
Function
Overexpression of GFPT2 counteracted the protective functions of miR-27a against myocardial infarction through the activation of the TGF-beta/Smad2/3 signaling pathway.